The Relation of Hypersensitiveness to Poison Ivy and to Cashew Nut Shell Liquid

Abstract
Cashew nut shell liquid, which is a commercially valuable product of the poison ivy family, produces a dermatitis. The raw liquid contains cardol, anacardic acid and anacardol as active ingredients. Persons sensitive to poison ivy were also sensitive to cardol, the raw oil, anacardic acid, anacardol and "cardanol," which is a monophenol isolated commercially from the oil. Cardol elicited the most intense group reactions. Hydrogenation of the components of the cashew liquid decreased the incidence and intensity of group reactivity. There was a difference in reactivity due to the 3 and 4 position of catechol.

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