PSEUDO ARIBOFLAVINOSIS

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Abstract
Sebrell and Butler1 in their classic discussion described the criteria for the diagnosis of ariboflavinosis in the human being. Among the signs pointed out by them were certain changes in the mucous membranes of the lips and the skin at the angles of the mouth, which they called a cheilosis. More specifically, there was a maceration in each angle of the mouth, the lips were reddened along the line of closure and the mucosa appeared thin, shiny and denuded. In addition to the lesions on the lips there was also a scaly, greasy desquamation in the nasolabial folds, on the alae nasi in the vestibule of the nose and in a few instances on the ears and eyelids. These lesions disappeared in twenty days or less when the patients were given from 0.025 to 0.075 mg. of riboflavin per kilogram of body weight. In addition to the cheilosis, Kruse,

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