Intermolecular Asymmetric Reductive Aldol Reaction of Ketones as Acceptors Promoted by Chiral Rh(Phebox) Catalyst
- 27 March 2007
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 9 (9) , 1651-1654
- https://doi.org/10.1021/ol070251d
Abstract
The conjugate reduction of cinnamates with hydrosilane and chiral Rh(Phebox-ip) catalyst in the presence of excess acetone is shown to provide the corresponding intermolecular reductive aldol product in extremely high enantioselectivity (up to 98%). Several cinnamates and crotonate substrates and several ketone acceptors were also examined.Keywords
This publication has 2 references indexed in Scilit:
- Highly Diastereo‐ and Enantioselective Copper‐Catalyzed Domino Reduction/Aldol Reaction of Ketones with Methyl AcrylateAngewandte Chemie International Edition in English, 2006
- High Performance of Rh(Phebox) Catalysts in Asymmetric Reductive Aldol Reaction: High Anti-SelectivityJournal of the American Chemical Society, 2005