Histochemical Study of Rosenthal Fibres, with Observations about some Enzyme Activities

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Abstract
Histological and histochemical data on Rosenthal fibres studied in 27 gliomas (25 cerebellar spon-gioblastoma, 1 oligodendroglioma and 1 astrocytoma), in 2 cases of cerebellar haemangioblastoma and in 3 cases of cerebral arteriosclerosis with granular ependymitis, are presented. In 3 cases of cerebellar spongioblastomas, the following enzyme activities have been studied: DPN and TPN Diaphorases, succinic-, lactic-, glucose-6-phosphate-, 6-phosphogluconate-, DPN- and TPN- linked isocitric-dehydrogenases, alkaline and acid phosphatases, nonspecific esterase and ATP-ase. The hypothesis is put forward that Rosenthal fibres originate from fibrils of subependymal glia. A strict relation between Rosenthal fibres and macrophage-like cells described by Zulch is pointed out. Rosenthal fibres are enzymatically inactive at all development stages, as well as inclusions of macrophages.

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