Critical Study of Staging in Multiple Myeloma

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Abstract
Patients (130) with multiple myeloma were reviewed for a retrospective study of their classification. No significant difference was found in survival between patients in stages I, II and III (median survival 24.8, 32.1 and 17.3 mo., respectively). Of the classical criteria affecting survival, only the Hb level showed any significant influence (P < 0.04). In accordance with this finding, the survival time was much shorter (P < 0.001) in patients with renal failure than in patients without (median survival 7.4 and 24.8 mo., respectively). Thrombopenia, fever, old age and, above all, the percentage of bone-marrow plasmocytes present were decisive factors.

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