Management of early stage Hodgkin's disease: The role of radiation therapy and/or chemotherapy
Open Access
- 1 August 1996
- journal article
- review article
- Published by Elsevier in Annals of Oncology
- Vol. 7, S79-S84
- https://doi.org/10.1093/annonc/7.suppl_4.s79
Abstract
Clinical trials in early stage Hodgkin's disease comparing radiation therapy (RT) alone versus chemotherapy (CMT) have indicated fewer relapses in the CMT groups. However, none of the trials have demonstrated an overall survival difference. Risk factors for relapse in early stages include large mediastinal adenopathy, fevers, and weight loss. Ongoing clinical trials might prove less toxic CMT effective in curing occult microscopic disease, perhaps eventually obviating the need for staging laparotomy and splenectomy.Keywords
This publication has 47 references indexed in Scilit:
- Extended-field radiotherapy is superior to MOPP chemotherapy for the treatment of pathologic stage I-IIA Hodgkin's disease: eight-year update of an Italian prospective randomized study.Journal of Clinical Oncology, 1992
- Long-term toxicity of early stages of Hodgkin's disease therapy: The EORTC experienceAnnals of Oncology, 1991
- A randomised study of adjuvant MVPP chemotherapy after mantle radiotherapy in pathologically staged IA-IIB Hodgkin's disease: 10-year follow-upAnnals of Oncology, 1991
- Individual risk of abdominal disease in patients with stages I and II supradiaphragmatic Hodgkin's disease. A rule index based on 341 laparotomized patientsCancer, 1990
- Extended mantle radiation therapy for pathologic stage I and II Hodgkin's disease.Journal of Clinical Oncology, 1988
- Clinical stages I and II Hodgkin's disease: a specifically tailored therapy according to prognostic factors.Journal of Clinical Oncology, 1988
- Stage I to IIB Hodgkin's disease: the combined experience at Stanford University and the Joint Center for Radiation Therapy.Journal of Clinical Oncology, 1987
- Clinical presentation as a predictor of laparotomy findings in supradiaphragmatic Stage I and II Hodgkin's diseaseRadiotherapy and Oncology, 1986
- The effective use of combined modality therapy for the treatment of patients with Hodgkinʼs disease who relapsed following radiotherapyAmerican Journal of Clinical Oncology, 1983
- Cure of Hodgkin's DiseaseBMJ, 1963