EFFECT OF FENFLURAMINE ON PROLACTIN SECRETION IN OBESE PATIENTS: EVIDENCE FOR SEROTONINERGIC REGULATION OF PROLACTIN IN MAN

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Abstract
The effect of serotoninergic stimulation on prolactin (PRL) secretion was studied in man. Fenfluramine (60 mg, orally), an anorexiant drug which under acute circumstances stimulates the serotoninergic system, was administered to 8 obese patients. Compared with placebo, drug administration increased PRL significantly (P < 0.05 at 180 and 300 min, P < 0.01 at 240 min). No significant changes were observed after fenfluramine in blood pressure, plasma aldosterone (PA), plasma cortisol, plasma renin activity, serum electrolytes or growth hormone. Since dopaminergic blockade raises PA concentration, the lack of change in PA in obese patients treated with fenfluramine suggests that the observed increase in PRL induced by fenfluramine is likely to be mediated by serotoninergic stimulation.

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