MISMATCHED HL-A HAPLOTYPES WITH ANTIGENS HL-A1, 3, AND 11 ASSOCIATED WITH EXCELLENT RENAL ALLOGRAFT FUNCTION
- 1 January 1973
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 15 (1) , 86-91
- https://doi.org/10.1097/00007890-197301000-00013
Abstract
SUMMARY In a no-exclusion study of 76 genotyped recipients of living related allografts, 51 received definitely mismatched haplotypes. Those mismatched haplotypes carrying the cross reacting antigens HL-A1,3, or 11 were associated with a significantly increased incidence of excellent functioning allografts—19—and only a single failure (P < 0.001). In those patients with a mismatched haplotype without HL-A1,3, or 11, allograft failures—13—exceeded excellent functioning allografts—11. Also evaluated were the possible roles of other donor cross reacting groups, donor-recipient cross reacting antigens, specific recipient antigens such as HL-A1, lymphocytotoxic, antinuclear, and anti-glomerular basement membrane antibodies (anti-GBM), the inflammatory response and delayed hypersensitivity (DH) to dinitrochlorobenzene (DNCB), preexisting DH, and the response of recipient lymphocytes to phytohemagglutinin.Keywords
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