An Unusual Case of Carbamazepine Poisoning with a Near-Fatal Relapse after Two Days
- 1 January 1979
- journal article
- case report
- Published by Taylor & Francis in Clinical Toxicology
- Vol. 14 (3) , 263-269
- https://doi.org/10.3109/15563657908992443
Abstract
A severe case of carbamazepine is described in which the drug and its major metabolite were monitored by means of HPLC. After 2 days of treatment a dramatic rise in plasma concentration of carbamazepine and its metabolite was observed, accompanied by a relapse into deep coma, then followed by a rapid elimination of the drugs and complete recovery within 4 days. The possible mechanisms underlying these phenomena and potential therapeutic measures are discussed.Keywords
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