MATURATIONAL EFFECTS OF THYMIC HORMONES ON HUMAN HELPER AND SUPPRESSOR T-CELLS - EFFECTS OF FTS (FACTEUR THYMIQUE SERIQUE) AND THYMOSIN

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 39  (3) , 722-727
Abstract
Human peripheral blood lymphocytes were isolated from healthy donors and pre-incubated with 2 thymic factors, FTS, a new synthetic polypeptide originally isolated and purified from serum, and thymosin fraction V. After 24 h of pre-incubation, the cells were washed and added to an allogeneic MLR [mixed lymphocyte reaction] and assayed for their ability to induce a suppressor or helper response. Both factors were capable of inducing helper and suppressor T [thymus-derived] cells and that the response was unpredictable. In both instances, more than 50% of the subjects studied responded with a helper effect. The addition of Con [concanavalin A] A augmented these effects. Since helper and suppressor T cells can be induced by the factors studied herein, one must be aware of the potential effects on T-T and T-B [bone marrow-derived] cell balances of manipulation in clinical situations such as SLE [systemic lupus erythematosus] or cellular immune deficiency states.