AN ANALYSIS OF THE PRESSOR RESPONSES TO PUTATIVE α1, AND α2‐ADRENORECEPTOR AGONISTS GIVEN INTRAVENOUSLY TO CONSCIOUS RABBITS

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Abstract
The selectivity of a range of .alpha.1 and .alpha.2-adrenoreceptor agonists was examined in the conscious rabbit. In this preparation the pressor responses to BHT 920 [alfexole], BHT933 [azapexole], guanabenz and .alpha.-methylnoradrenaline [a-methylnorepinephrine] were attenuated by idazoxan but not by prazosin. The pressor responses to clonidine and noradrenaline [norepinephrine] were attenuated by both idazoxan and prazosin while the response to phenylephrine was only significantly attenuated by prazosin. Both an immediate pressor response and a later depressor response to clonidine was observed but there were no depressor components to either BHT 920 or BHT 933 responses. Pressor responses to guanabenz were attentuated on repeated dosing.