Superfolding of the Partially Unfolded Core-glycosylated Intermediate of Human P-glycoprotein into the Mature Enzyme Is Promoted by Substrate-induced Transmembrane Domain Interactions
Open Access
- 1 June 1998
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 273 (24) , 14671-14674
- https://doi.org/10.1074/jbc.273.24.14671
Abstract
No abstract availableKeywords
This publication has 15 references indexed in Scilit:
- Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and ModulatorsJournal of Biological Chemistry, 1997
- Diagnosis and reversal of multidrug resistance in paediatric cancersEuropean Journal Of Cancer, 1996
- Mutational Analysis of the Predicted First Transmembrane Segment of Each Homologous Half of Human P-glycoprotein Suggests That They Are Symmetrically Arranged in the MembraneJournal of Biological Chemistry, 1996
- P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans.Proceedings of the National Academy of Sciences, 1996
- GENETIC ANALYSIS OF THE MULTIDRUG TRANSPORTERAnnual Review of Genetics, 1995
- Rapid Purification of Human P-glycoprotein Mutants Expressed Transiently in HEK 293 Cells by Nickel-Chelate Chromatography and Characterization of their Drug-stimulated ATPase ActivitiesPublished by Elsevier ,1995
- P-glycoproteinJournal of Biological Chemistry, 1995
- P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic SitePublished by Elsevier ,1995
- Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugsPublished by Elsevier ,1994
- Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.Molecular and Cellular Biology, 1989