GUANINE-NUCLEOTIDE REGULATORY PROTEINS AS TRANSDUCERS OF RECEPTOR-STIMULATED NEUTROPHIL ACTIVATION

1 January 1987

journal article
research article

Vol. 9 (4) , 285-293

Abstract

There exists a family of homologous GTP-binding regulatory proteins (the G proteins) which couple receptors to cellular effector systems. Several lines of evidence indicate a major role for a G protein in mediating neutrophil activation by a variety of chemotactic factors. We here describe studies on guanine nucleotide regulation of formyl peptide recetor affinity in a permeabilized neutrophil preparation. The characterization of neutrophil G protein with anti-G protein antibodies is also discussed.

This publication has 1 reference indexed in Scilit:

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
Proceedings of the National Academy of Sciences, 1979