Statistical Analysis of Relative Labeled Mass Spectrometry Data from Complex Samples Using ANOVA
- 1 January 2008
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Proteome Research
- Vol. 7 (1) , 225-233
- https://doi.org/10.1021/pr700734f
Abstract
Statistical tools enable unified analysis of data from multiple global proteomic experiments, producing unbiased estimates of normalization terms despite the missing data problem inherent in these studies. The modeling approach, implementation, and useful visualization tools are demonstrated via a case study of complex biological samples assessed using the iTRAQ relative labeling protocol.Keywords
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