Effects of Atropine on Platelet Structure and Function

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Abstract
The aggregation of blood platelets occurs in two phases. Primary clumping results from the action of aggregating agents on cell membranes, and the second wave is caused by adenosine diphosphate and catacholamines released from platelets. Several groups of drugs have been described which specifically inhibit the second wave of aggregation. The present report has explored the influence of atropine on platelet structure and physiology. Atropine had no effect on platelet fine structure, but inhibited the second wave of aggregation produced in citrate platelet rich plasma by small concentrations of adenosine diphosphate and epinephrine. In contrast to other agents which block secondary aggregation, atropine also prevents clot retraction. A possible basis for the action of atropine on platelets is discussed.