Venous Extravasation of Doxorubicin HCl With Secondary Skin Ulceration

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Abstract
With increased use of the potent anticancer drug doxorubicin hydrochloride (Adriamycin), there are increasing numbers of reports of local severe tissue damage at the venous administration sites. A 70 yr old woman is described in whom extravasation of this drug produced a characteristic indolent ulcer on the hand and wrist. Expectant nonoperative care was followed 6 wk later by debridement and a split-thickness skin graft which failed to take. Repeat debridement with porcine grafts stimulated granulation tissue, so that split-thickness skin grafting could give an acceptable functional and cosmetic result.

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