INFLUENCE OF T-CELLS ON THE INITIATION AND EXPRESSION OF IMMUNOLOGICAL MEMORY

  • 1 January 1979
    • journal article
    • research article
    • Vol. 38  (2) , 265-274
Abstract
Nude and normal CBA mice were used in adoptive transfer experiments to analyze immunological memory development. Development of B[bone marrow-derived] cell memory to xenogeneic erythrocyte antigens [Ag] is greatly dependent on presence of T [thymus-derived] cells with Ig[immunoglobulin]G memory being somewhat more dependent than IgM memory. The expression of B cell memory, i.e., transformation of memory cells to antibody-secreting cells under the inductive influence of Ag, is largely dependent on T cell presence. Primed (educated) T cells can have an Ag-specific potentiating effect on unprimed B cells in the presence of Ag.