Thermogenic Responses of Brown Adipocytes to Noradrenaline and Glucagon in Heat-acclimated and Cold-acclimated Rats

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Abstract
Heat production of isolated brown-fat cells by addition of noradrenaline [norepinephrine] and glucagon was measured in warm-acclimated control, cold-acclimated and heat-acclimated rats by a twin-type conduction microcalorimeter. Noradrenaline and glucagon induced maximum heat production per 106 cells in dose of 1 .mu.g/ml. Heat produced by maximum thermogenic response to glucagon was 2x as much as that to noradrenaline. Thermogenic response to noradrenaline was markedly increased in cold-acclimated brown adipocytes, it was reduced in heat-acclimated ones. Thermogenic response to glucagon was significantly reduced in heat-acclimated brown adipocytes; was not affected in cold-acclimated brown adipocytes.

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