INCREASED INCIDENCE OF INSULIN-DEPENDENT DIABETES MELLITUS IN PEDIATRIC RENAL TRANSPLANT PATIENTS RECEIVING TACROLIMUS (FK506)

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Abstract
Background. Use of tacrolimus (FK506), a potent immunosuppressive agent, has been reported to have a 10-20% incidence of insulin-dependent diabetes mellitus (IDDM) in adults, but the incidence of IDDM in pediatric renal transplant recipients treated with this agent is unknown. In this article, we report our single-center experience with FK506-induced IDDM in children. Methods. Five consecutive living related donor pediatric renal transplants were reviewed retrospectively. Results. All five patients developed IDDM lasting longer than 6 months. Mean follow-up time was 18.6 months. Conclusions. Pediatric patients may be at high risk for developing FK506-induced IDDM.