3-(Cyclohexenonyl)-4-(4-hydroxyphenyl)-hexanes: Antiandrogenes Derived from the Estrogen Hexestrol
- 1 January 1990
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 323 (7) , 417-420
- https://doi.org/10.1002/ardp.19903230708
Abstract
Selective Birch-reduction of one of the phenolic rings of meso- or d, l-HES led to compounds 6a and 6b which exert a higher binding affinity to the androgen receptor as the respective parent HES. In vivo testing of 6a and 6b shows that 6a has the same potency in reducing accessory sex organ weights and testosterone levels in the intact mouse as has meso-HES, but strongly decreased estrogenic activity. Syntheses and testing of 7 having no ethyl side chains revealed the necessity of these groups for biological activity.This publication has 7 references indexed in Scilit:
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