Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidasesElectronic supplementary information (ESI) available: details of data and structure quality for complex of cel6A with 1. See http://www.rsc.org/suppdata/cc/b3/b301592k/
- 20 March 2003
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 8,p. 946-947
- https://doi.org/10.1039/b301592k
Abstract
A cellobio-derived isofagomine glycosidase inhibitor (Ki ∼ 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.Keywords
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