The Use of Drugs in Combination for the Treatment of Cancer

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Abstract
INTEREST in the use of drugs in combination tor the treatment of cancer is not a new phenomenon. It stems from the inability to obtain entirely satisfactory results when available agents are given singly. Theoretical interest in this area can be traced back more than 10 years with the work of Goldin,1 Potter,2 Elion,3 Skipper,4 and Lepage and Sartorelli.5 6 7 The first major clinical effort began in the late 1950's, with the use of drug combinations in the treatment of neoplasms of the testes and other tumors.8 , 9 The current intensity of the interest in this approach derives from two major sources. . . .