Trace Metal-Citric Acid Complexes as Inhibitors of Calcification and Crystal Growth
- 1 December 1982
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 128 (6) , 1372-1375
- https://doi.org/10.1016/s0022-5347(17)53510-7
Abstract
The crystal growth of calcium phosphate has been shown to be inhibited by a low molecular weight Fe(III)-citric acid complex formed when there are high ratios of citratedron at neutral pH in aqueous solution. Synergism with citric acid was also observed in systems containing Al(III) or Cr(III) ion, but different unknown complexes seemed to be involved. These results are in qualitative agreement with a preceding study involving calcification of an organic matrix. Since chelating agents like citric acid can compete with the storage proteins for iron, we suggest that the Fe (III)-citrate complexes studied here may be formed in vivo and participate in regulating biologic calcification.This publication has 24 references indexed in Scilit:
- Structure of sodium ferric citrateJournal of Inorganic and Nuclear Chemistry, 1979
- A thermodynamic analysis of the amorphous to crystalline calcium phosphate transformationCalcified Tissue International, 1978
- A thermodynamic analysis of the secondary transition in the spontaneous precipitation of calcium phosphateCalcified Tissue International, 1978
- A scanning electron microscopic study of the growth of hydroxyapatite crystalsCalcified Tissue International, 1972
- Hydrolytic polymerization of ferric citrate. II. Influence of excess citrateJournal of the American Chemical Society, 1967
- Hydrolytic polymerization of ferric citrate. I. Chemistry of the polymerJournal of the American Chemical Society, 1967
- The Hydrolytic Polymerization of Iron(III)Journal of the American Chemical Society, 1966
- The Cupric and Ferric Citrate Complexes1Journal of the American Chemical Society, 1953
- A Spectrophotometric Study of the Reaction of Ferric Iron and Citric AcidJournal of the American Chemical Society, 1948
- The Structure and Behavior of Ferric Tartrate and Citrate Complexes in Dilute Solutions1Journal of the American Chemical Society, 1947