Alterations in Response to Somatic Pain Associated with Anaesthesia XV: Further Studies with Phenothiazine Derivatives and Similar Drugs
Open Access
- 1 October 1963
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 35 (10) , 597-610
- https://doi.org/10.1093/bja/35.10.597
Abstract
The effect of phenothiazine derivatives on the response to somatic pain varies with time elapsing after administration. All drugs first increase sensitivity to pain and this is followed by a slight analgesic action. The time-response curve of drugs differs appreciably, so that, when given as pre-anaesthetic medication 60–90 minutes before operation, some will have at this time an analgesic effect and others will show varying degrees of antanalgesia. The size of this dose affects these changes in a quantitative but not qualitative manner. It is possible to make certain correlations between the analgesic or antanalgesic actions of these drugs and their chemical structure. Antanalgesic phenothiazines can partially antagonize the analgesic action of pethidine.Keywords
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