INTRA-ARTERIAL ADMINISTRATION OF PENICILLIN WITH SPECIAL REFERENCE TO BONE MARROW CONCENTRATION

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Abstract
THE RATIONALE of the intra-arterial injection of antiseptic substances was formulated by Parlavecchio1 in 1899. From his experimental observations he concluded that the procedure was a feasible method of obtaining a high concentration of therapeutic agent in a diseased tissue. In his report he suggested that the presence of a peripheral capillary field, in addition to the pulmonary circuit, through which a substance so injected must pass before it could reach the brain and other viscera, tended to minimize any toxic effect. These assumptions have formed the logical basis for the sporadic clinical reports that have since appeared. The advent of penicillin served as a stimulus to trial of this technic. In 1944, Ribeiro2 treated a patient with purulent osteoarthritis of the knee by repeated injections into the femoral artery. At the same time, Gudin and Neiva Filho3 successfully treated 2 patients with osteomyelitis who previously had

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