Synthesis and Bioactivity of Novel Bis(heteroaryl)piperazine (BHAP) Reverse Transcriptase Inhibitors: Structure−Activity Relationships and Increased Metabolic Stability of Novel Substituted Pyridine Analogs

This publication has 17 references indexed in Scilit:

• An Efficient Synthesis of Aromatic Acetonyl Imines
  The Journal of Organic Chemistry, 1995
• Discovery, Synthesis, and Bioactivity of Bis(heteroaryl)piperazines. 1. A Novel Class of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
  Journal of Medicinal Chemistry, 1994
• Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replication.
  Proceedings of the National Academy of Sciences, 1991
• Characterization of DNA metabolizing enzymes in situ following polyacrylamide gel electrophoresis
  Biochemistry, 1991
• Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran 2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus
  Journal of Medicinal Chemistry, 1991
• Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor
  Science, 1990
• Denaturation/Refolding of Purified Recombinant HIV Reverse Transcriptase Yields Monomeric Enzyme with High Enzymatic Activity
  AIDS Research and Human Retroviruses, 1990
• Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives
  Nature, 1990
• A new method for the preparation of tertiary butyl ethers and esters
  Tetrahedron Letters, 1988
• The catalytic demethylation of N,N-dimethylaniline-N-oxide by liver microsomes
  Biochemical and Biophysical Research Communications, 1963