Effects of intraventricular injections of gamma-aminobutyric acid and related substances on feeding behavior in satiated sheep

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Abstract
Feed intake was measured following injections of GABA, muscimol (a GABA agonist) and picrotoxin (a GABA antagonist) into the lateral ventricles of satiated sheep. Doses ranging from 0.20-3200 nmol of GABA did not affect feeding behavior at 15, 30, 60 and 120 min postinjection. A dose of 160 nmol of muscimol induced a marked increase in feeding, comparable to that provoked by an injection of 78 .mu.mol of pentobarbital. Muscimol-induced feeding was blocked effectively by a preinjection of picrotoxin. Neurons sensitive to GABA may be involved in the control of feeding behavior in ruminants.