Ephedrine Determination in Human Urine Using a Carbon Paste Electrode Modified with C18Bonded Silica Gel
- 1 July 1994
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 27 (10) , 1809-1831
- https://doi.org/10.1080/00032719408002634
Abstract
An electrochemical method by adsorptive stripping voltammetry with a modified carbon paste electrode with C18 bonded silica gel is described for the determination of ephedrine in human urine samples. The preconcentration step is performed at open circuit and constant stirring (1000 rpm) in 5×10−4 M sodium hydroxide and the measurement step in ammonia-ammonium chloride buffer (pH=10.0; 0.2 M) by linear scan voltammetry to 150 mVs−1 between 0.20 and 1.10 V. With the proposed method, ephedrine can be directly determined in urine, a relative standard deviation of 3.4% (n=12) and a detection limit of 270 μgmL−1 for a 2 minute preconcentration time, were obtained.Keywords
This publication has 22 references indexed in Scilit:
- Determination of ephedrine in human urine using a glassy carbon electrodeAnalytica Chimica Acta, 1993
- Electrochemical label for high-performance liquid chromatography : I. β-Naphthoquinone-4-sulphonate as an electrochemical detection labelling reagent of aminesJournal of Chromatography B: Biomedical Sciences and Applications, 1989
- Identification of doping agents by chromatographic techniques and UV spectrophotometryThe Analyst, 1988
- Liquid membrane electrode for the direct determination of ephedrine in pharmaceutical preparationsThe Analyst, 1986
- Sensitive assay for pseudoephedrine and its metabolite, norpseudoephedrine in plasma and urine using gas—liquid chromatography with electron-capture detectionJournal of Chromatography B: Biomedical Sciences and Applications, 1981
- Microdetermination of stimulant drugs in urine by high-performance liquid chromatographyJournal of Chromatography A, 1980
- Microencapsulation and Dissolution Parameters of Undecenovanillylamide: A Potential Coyote DeterrentJournal of Pharmaceutical Sciences, 1979
- Anodic oxidation of amines. V. Cyclic voltammetry and controlled potential electrolysis of ephedrine and the related compounds in aqueous buffer solution.CHEMICAL & PHARMACEUTICAL BULLETIN, 1978
- Gas-liquid chromatographic determination of pseudoephedrine and norpseudoephedrine in human plasma and urineJournal of Chromatography A, 1977
- Dissociation Constants of Adrenergic Amines1Journal of the American Chemical Society, 1951