Preparation of 4-alkylprolines by intramolecular radical cyclization of chiral serine derivatives
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 11,p. 2885-2887
- https://doi.org/10.1039/p19910002885
Abstract
N-Alkylation of the β-lactone derived from Boc-L-serine followed by ring opening with sodium benzeneselenoate provides chiral substrates which undergo intramolecular radical cyclization to afford cis/trans mixtures of 4-alkyl-L-prolines.Keywords
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