Evidence for widespread effects of noradrenaline on axon terminals in the rat frontal cortex.
- 1 February 1985
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 82 (3) , 945-947
- https://doi.org/10.1073/pnas.82.3.945
Abstract
Noradrenaline, apparently working through activation of beta-adrenergic receptors, alters the state of phosphorylation of a substantial proportion of synapsin I in rat frontal cortex. Since synapsin I is enriched in virtually all axon terminals in this brain region, the results indicate that noradrenaline, a sparsely distributed neurotransmitter, affects a large number of axon terminals in this region. The results also suggest that noradrenaline receptors are present on a substantial percentage of all axon terminals in the cerebral cortex, despite the low density of noradrenergic fibers present. The data support the view that noradrenaline may serve a paracrine function.This publication has 20 references indexed in Scilit:
- Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation.The Journal of cell biology, 1983
- Synapsin I (Protein I), a nerve terminal-specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes.The Journal of cell biology, 1983
- Synapsin I (protein I), a nerve terminal-specific phosphoprotein. I. Its general distribution in synapses of the central and peripheral nervous system demonstrated by immunofluorescence in frozen and plastic sections.The Journal of cell biology, 1983
- Ultrastructural demonstration of noradrenergic synapses in the rat central nervous system by dopamine-beta-hydroxylase immunocytochemistry.Journal of Histochemistry & Cytochemistry, 1981
- Serotonin stimulates phosphorylation of Protein I in the facial motor nucleus of rat brainNature, 1981
- Noradrenergic axon terminals in the cerebral cortex of rat. III. Topometric ultrastructural analysisBrain Research, 1977
- Characteristics of dopamine and β-adrenergic sensitive adenylate cyclases in the frontal cerebral cortex of the rat. Comparative effects of neuroleptics on frontal cortex and striatal dopamine sensitive adenylate cyclasesBrain Research, 1977
- A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry, 1976
- 5‐HYDROXYTRYPTAMINE AND NORADRENALINE IN THE HIPPOCAMPAL REGION: EFFECT OF TRANSECTION OF AFFERENT PATHWAYS ON ENDOGENOUS LEVELS, HIGH AFFINITY UPTAKE AND SOME TRANSMITTER‐RELATED ENZYMESJournal of Neurochemistry, 1974
- Noradrenergic axon terminals in the cerebral cortex of rat. II. Quantitative data revealed by light and electron microscope radioautography of the frontal cortexBrain Research, 1973