Limitations of hepatocytes and liver homogenates in modelling in vivo formation of acyl glucuronide-derived drug–protein adducts
- 1 February 1999
- journal article
- research article
- Published by Elsevier in Journal of Pharmacological and Toxicological Methods
- Vol. 41 (1) , 27-32
- https://doi.org/10.1016/s1056-8719(99)00014-3
Abstract
No abstract availableKeywords
This publication has 11 references indexed in Scilit:
- Zomepirac acyl glucuronide covalently modifies tubulin in vitro and in vivo and inhibits its assembly in an in vitro systemChemico-Biological Interactions, 1998
- Selective Protein Adduct Formation of Diclofenac Glucuronide Is Critically Dependent on the Rat Canalicular Conjugate Export Pump (Mrp2)Chemical Research in Toxicology, 1998
- The utility of the bile-exteriorized rat as a source of reactive acyl glucuronides: Studies with zomepiracJournal of Pharmacological and Toxicological Methods, 1996
- Chemical and Immunochemical Comparison of Protein Adduct Formation of Four Carboxylate Drugs in Rat Liver and PlasmaChemical Research in Toxicology, 1996
- Covalent Modification of Rat Liver Dipeptidyl Peptidase IV (CD26) by the Nonsteroidal Anti-Inflammatory Drug DiclofenacChemical Research in Toxicology, 1995
- Metabolic Activation and Immunochemical Localization of Liver Protein Adducts of the Nonsteroidal Anti-inflammatory Drug DiclofenacChemical Research in Toxicology, 1994
- Acyl Glucuronides as Chemically Reactive IntermediatesPublished by Springer Nature ,1994
- Acyl Glucuronides Revisited: Is the Glucuronidation Proces a Toxification as Well as a Detoxification Mechanism?Drug Metabolism Reviews, 1992
- Properties of Acyl Glucuronides: Implications for Studies of the Pharmacokinetics and Metabolism of Acidic DrugsDrug Metabolism Reviews, 1984
- HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLSThe Journal of cell biology, 1969