Intrinsic particles in angiographic contrast media.

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Abstract
The 5 brands of water-soluble contrast media (sodium methylglucamine 60%) used most often for cerebral angiography in Europe were investigated for contamination with intrinsic nonviable particles. A Coulter counter was used to screen particles by size (5-10 .mu., 10-30 .mu., and > 30 .mu.), and scanning electron microscopy (SEM) combined with energy-dispersive X-ray analysis (EDAX) was used to verify the findings. Particles were found in the solutions, both from ampules and vials. The mean was 302 particles > 5 .mu. in 1 ml of contrast medium contained in ampules; a few particles measuring up to 500 .mu. were found. EDAX analysis revealed Ca, Cl, Co, Cr, Fe, I, K, Mn, Na, Si and Zn. Contrast media should be passed through a filter with a pore size of 5 .mu. or less.

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