Novel and potential future biomarkers for assessment of the severity and prognosis of chronic heart failure
- 1 December 2006
- journal article
- review article
- Published by Springer Nature in Heart Failure Reviews
- Vol. 11 (4) , 333-334
- https://doi.org/10.1007/s10741-006-0234-x
Abstract
Over the last two decades, the pathophysiology and biomolecular basis of heart failure syndrome has reached sound and more comprehensive understanding. This knowledge has allowed expert researchers and clinicians to explore an entirely new spectrum of potential biochemical markers derived from different cellular and signaling pathways that lead to myocardial hypertrophy, chronic damage of the myocyte, apoptosis, and, ultimately, myocardial remodeling. Indeed, the link between myocardial remodeling and adverse outcomes, as well as the recognition of the myocardial interstitium as a multifunctional dynamic entity strongly influenced by systemic neurohormonal and inflammatory activation, has provided a solid ground for research of biomarkers that might correlate with severity and prognostication in chronic heart failure. This paper reviews and summarize recent literature on some of the most interesting circulating biomarkers with potential use for the stratification of patients with chronic heart failure.Keywords
This publication has 127 references indexed in Scilit:
- Circulating matrix metalloproteinase-2 but not matrix metalloproteinase-3, matrix metalloproteinase-9, or tissue inhibitor of metalloproteinase-1 predicts outcome in patients with congestive heart failureAmerican Heart Journal, 2005
- Effects of repeated injection of local anesthetic on sciatic nerve blocks responseJournal of Huazhong University of Science and Technology [Medical Sciences], 2004
- Role of heart-type fatty acid binding protein in early detection of acute myocardial infarction in comparison with cTnI, CK-MB and myoglobinJournal of Huazhong University of Science and Technology [Medical Sciences], 2004
- Urinary biopyrrins levels are elevated in relation to severity of heart failureJournal of the American College of Cardiology, 2004
- Adrenomedullin: Its Role in the Cardiovascular SystemSeminars in Vascular Medicine, 2004
- Implications of elevated cardiac troponin t in ambulatory patients with heart failure: a prospective analysisAmerican Heart Journal, 2004
- N-terminal pro B type natriuretic peptide, but not the new putative cardiac hormone relaxin, predicts prognosis in patients with chronic heart failureHeart, 2003
- Increased urinary 15-F2t-isoprostane concentrations in patients with non-ischaemic congestive heart failure: a marker of oxidative stressHeart, 2003
- Do cytokines enable risk stratification to be improved in NYHA functional class III patients?. Comparison with other potential predictors of prognosisEuropean Heart Journal, 2002
- An Immunoluminometric Assay for Cardiotrophin-1: A Newly Identified Cytokine Is Present in Normal Human Plasma and Is Increased in Heart FailureBiochemical and Biophysical Research Communications, 1999