Abstract
In family studies the question arises whether a certain characteristic, usually an abnormality, occurs among early or late births or at random among all births. Using data on celiac children in 100 human families, the method of Haldane and Smith (1947-49) is employed to test the hypothesis of randomness. This method is exact but tedious, and several short-cut techniques are discussed. One of these, based on a regression approach, is shown to approximate the exact test very closely.

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