Dehydration of Amides to Nitriles Initiated by Hexamethylphosphoric Triamide

1 September 1971

journal article
Published by Canadian Science Publishing in Canadian Journal of Chemistry

Vol. 49 (17) , 2897-2898
https://doi.org/10.1139/v71-480

Abstract

Aliphatic and aromatic carboxamides are found to undergo ready dehydration in hexamethylphosphoric triamide at 220–240° affording the corresponding nitriles in good yield.

Keywords

NITRILES
AROMATIC
DEHYDRATION
GOOD
ALIPHATIC
CARBOXAMIDES
CORRESPONDING
READY
UNDERGO