A Possible Role of Gonad and Renal Prostaglandin E2 on the Development of Hypertension in Spontaneously Hypertensive Rats*

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Abstract
A possible role of prostaglandin E2 (PGE2) in the regulation of blood pressure in spontaneously hypertensive rats (SHR) was investigated. The inhibition of PG synthesis by chronic indomethacin treatment accelerated the elevation of blood pressure with the tendency to decrease renal PGE2. It was confirmed that PGE2 in SHR may play a role in the antihypertensive mechanism. In this connection, the participation of renal PGE2 in the retardation of the development of hypertension in male SHR induced by orchiectomy was examined. Urinary PGE2 which reflects the renal PGE2 level tended to keep a higher level in the castrated group. Urinary electrolytes excretion also inclined to augment in the castrated group throughout the experiment. Renal PGE2 may participate in the gonad-mediated blood pressure regulation system, although the mechanism of the retardation of spontaneous hypertension induced by orchiectomy remains obscure.