Radiosulfate Incorporation in Rat Gastric Mucosa: Effect of the Length of the Restraint

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Abstract
The radioactivity was measured after proteolysis and dialysis in the gastric mucosa of 100 rats killed 6 h after injection of 100 µC of carrier-free radiosulfate. Controls were paired to rats restrained respectively 6, 12, 18 or 24 h. The radiosulfate metabolism was always assessed in the last 6 h. Non-dialyzable radiosulfate, index of the synthetized sulfated macromolecules, is significantly decreased in the gastric mucosa of the restrained animals. The values vary between 54 and 77% of controls. A defect in radiosulfate incorporation during the first, pre-ulcerous period of restraint is thus demonstrated. This alteration is observed earlier than the lesions in gastric mucosa, indicating that the metabolic disturbance is a significant factor in ulcerogenesis.

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