Anticellular Effects of 9-(2-Hydroxyethoxymethyl) Guanine Against Herpes Simplex Virus-transformed Cells

1 October 1979

journal article
Published by Microbiology Society in Journal of General Virology

Vol. 45 (1) , 227-230
https://doi.org/10.1099/0022-1317-45-1-227

Abstract

Summary The guanine derivative 9-(2-hydroxyethoxymethyl) guanine (acycloguanosine), a potent inhibitor of herpes simplex virus (HSV) multiplication, was found to have marked anticellular activity against HSV-transformed thymidine kinase-positive cells. HSV type 1-transformed cells were more sensitive to the drug than HSV type 2-transformed cells.

Keywords

HERPES SIMPLEX VIRUS
TRANSFORMED CELLS
HYDROXYETHOXYMETHYL
GUANINE
ANTICELLULAR EFFECTS
DRUG
HSV TYPE

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