Saprophytic production of Clavine alkaloids and activity of Hydroxymethylglutaryl-CoA reductase
- 1 August 1986
- journal article
- research article
- Published by Springer Nature in Folia Microbiologica
- Vol. 31 (4) , 282-287
- https://doi.org/10.1007/bf02926952
Abstract
In submergedClaviceps cultures the activity of hydroxymethylglutaryl-CoA reductase preceded the increase of alkaloid production and of sterol content. During the first alkaloid phase, cell mevalonate was involved in the biosynthesis of both alkaloids and steroids. In the second production phase, it was predominantly used for alkaloid synthesis. Hydroxymethylglutaryl-CoA reductase appears to be a suitable target for physiological manipulation to increase clavine alkaloid yields.This publication has 26 references indexed in Scilit:
- The effect of uremia on circulating mevalonate metabolism in ratsMetabolism, 1983
- The mechanism of action of mevalonate-5-pyrophosphate decarboxylaseTrends in Biochemical Sciences, 1983
- The Effects of Catabolite Derepression on the Accumulation of Steryl Esters and the Activity of -Hydroxymethylglutaryl-CoA Reductase in Saccharomyces cerevisiaeJournal of General Microbiology, 1979
- Analysis of ergot alkaloids by high-performance liquid chromatographyJournal of Chromatography A, 1978
- Purification and properties of dimethylallylpyrophosphate: Tryptophan dimethylallyl transferase, the first enzyme of ergot alkaloid biosynthesis in Claviceps. sp. SD 58Archives of Biochemistry and Biophysics, 1976
- Autolysis of Extracellular Glucans Produced in vitro by a Strain of Claviceps fusiformisJournal of General Microbiology, 1970
- N6-(δ2-Isopentenyl)adenosine: Chemical Reactions, Biosynthesis, Metabolism, and Significance to the Structure and Function of †RNAProgress in Nucleic Acid Research and Molecular Biology, 1970
- Biosynthesis of ergot alkaloids: stereochemistry of hydrogen elimination from C-4 of mevalonateChemical Communications (London), 1967
- The biosynthesis of the ergot alkaloidsTetrahedron Letters, 1960
- BETA-ERGOSTENOLJournal of the American Chemical Society, 1932