Flecainide

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Abstract
FLECAINIDE acetate (Tambocor, Riker Laboratories) has recently become available in this country for the management of ventricular arrhythmias. The synthesis of flecainide in 1972 was the culmination of a systematic search for fluorinated local anesthetic analogues of procainamide (Fig. 1).1 Early screening experiments showed that this structure, N-(2-Piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy) benzamide, was active in a variety of animal models of arrhythmia.2 Clinical testing of the agent began in 1975. Only oral flecainide is currently available, although an intravenous form is under investigation.Flecainide is the first of a number of agents with similar electrophysiologic properties to be approved in the United . . .

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