Effect of Controlled Ascorbic Acid Ingestion Upon Urinary Excretion and Plasma Concentration of Ascorbic Acid in Normal Adults

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Abstract
Urinary excretion of ascorbic acid and fasting plasma ascorbic acid values were determined daily in six normal adult subjects, two men and four women, during twenty-one 28-day periods on controlled intakes of ascorbic acid. In general, lower urinary and plasma ascorbic acid values were observed on the lower levels of intake but there were marked variations in the same subject from day to day, and between individual subjects. There was a definite correlation between the daily urinary excretion and the plasma concentration of ascorbic acid on the lower levels but not on the higher levels of ascorbic acid intake. As estimated from the response to the test dose at the conclusion of each experimental period, supplements of from 65 to 150 mg. of ascorbic acid, in addition to approximately 10 mg. in the basal diet, were required by the subjects in this study to maintain tissue saturation.