Rapid Emergence of Protease Inhibitor Resistance in Hepatitis C Virus
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- 5 May 2010
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Translational Medicine
- Vol. 2 (30) , 30ra32
- https://doi.org/10.1126/scitranslmed.3000544
Abstract
Computational modeling suggests that the rapid emergence of resistance to drugs against hepatitis C virus is a result of preexisting resistant virus and potent suppression of wild-type virus.Keywords
This publication has 64 references indexed in Scilit:
- Genetic variation in IL28B and spontaneous clearance of hepatitis C virusNature, 2009
- GT-1a or GT-1b Subtype-Specific Resistance Profiles for Hepatitis C Virus Inhibitors Telaprevir and HCV-796Antimicrobial Agents and Chemotherapy, 2009
- Telaprevir with Peginterferon and Ribavirin for Chronic HCV Genotype 1 InfectionNew England Journal of Medicine, 2009
- Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patientsHepatology, 2008
- The Hepatitis C Virus Replicon Presents a Higher Barrier to Resistance to Nucleoside Analogs than to Nonnucleoside Polymerase or Protease InhibitorsAntimicrobial Agents and Chemotherapy, 2008
- Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses?Journal of Antimicrobial Chemotherapy, 2008
- Phenotypic Characterization of Resistant Val36Variants of Hepatitis C Virus NS3-4A Serine ProteaseAntimicrobial Agents and Chemotherapy, 2008
- VX-950, a Novel Hepatitis C Virus (HCV) NS3-4A Protease Inhibitor, Exhibits Potent Antiviral Activities in HCV Replicon CellsAntimicrobial Agents and Chemotherapy, 2006
- Hepatoimmunology: A perspectiveImmunology & Cell Biology, 2002
- Decay characteristics of HIV-1-infected compartments during combination therapyNature, 1997