Evolutionary divergence of genes for ornithine and aspartate carbamoyl-trasferases-complete sequence and mode of regulatio of theEscherichia coli argFgene; comparison ofargFwithargIandpyrB
- 10 August 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 12 (15) , 6277-6289
- https://doi.org/10.1093/nar/12.15.6277
Abstract
The complete nucleotide sequence of argF is presented, together with that of an operator-constitutive mutant. ArgF is compared with the other gene coding for ornithine carbamoyltransferase (OTCase) in E. coli K-12, argI, and with pyrB, encoding the catalytic monomer of aspartate carbamoyltransferase (ATCase). ArgF and argI appear very closely related having emerged from a relatively recent ancestor gene. The relationship between OTCase and ATCase appears more distant. Nevertheless, the homology observed between the two proteins (mainly in the polar domain) suggests a common origin.Keywords
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