FORMATION OF DES-ASP-ANGIOTENSIN II IS NOT AN OBLIGATORY STEP IN THE STEROIDOGENIC ACTION OF ANGIOTENSIN II IN THE CANINE ADRENAL
- 1 June 1978
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 102 (6) , 1921-1924
- https://doi.org/10.1210/endo-102-6-1921
Abstract
A comparison of the receptor binding properties and in vitro metabolism of angiotensin [A] II and [des-Asp1]-A II was performed in collagenase-dispersed glomerulosa cells from dog adrenal glands. Each peptide was bound rapidly and reversibly to isolated glomerulosa cells, with similar equilibrium and kinetic constants of association and dissociation. The labeled peptide that was bound to glomerulosa cells after incubation with 125I- and 3H-A II at 37.degree. C for 30-60 min was predominantly A II, with about 15% [des-Asp1]-A II. Local formation of the heptapeptide is not an obligatory step in the action of A II on aldosterone production in the canine adrenals.This publication has 2 references indexed in Scilit:
- Specific receptors for des-Asp1-angiotensin II (("angiotensin III") in rat adrenals.Proceedings of the National Academy of Sciences, 1977
- Actions of Angiotensin II Antagonists upon Aldosterone Production by Isolated Adrenal Glomerulosa CellsEndocrinology, 1976