Effects of Radiotoxic Dosages of I131 upon Thyroid and Contiguous Tissues in Mice.

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Abstract
Radioactive I (I131 as Nal) was given in a single subcut. injn. in doses ranging from 3-50 millicuries/kg. Higher doses produced complete thyroid destruction within a few days. Lower doses permitted survival of some thyroidal epithelium in the isthmus and cranial apex of the gland for as long as 120 days after injn. Lesions were noted in the tracheal epithelium with all doses, and in the recurrent laryngeal nerve with higher dosages.