Adsorption of benzoic acid on sulphadimidine: suppressive effect of some hydrophilic polymers
- 1 February 1973
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 25 (2) , 138-142
- https://doi.org/10.1111/j.2042-7158.1973.tb10607.x
Abstract
The uptake of benzoic acid on sulphadimidine particles has been investigated. Depending on the concentration of sulphadimidine in the system, benzoic acid was adsorbed to the extent of 94%. Data from the adsorption experiments were shown to fit a Langmuir plot for systems containing up to 0.2 g 100 ml−1 sulphadimidine. The suppressive effect of three hydrophilic polymers on adsorption was studied; the results followed the sequence: Polyvinylpyrrolidone (PVP) > methylcellulose > sodium carboxymethylcellulose. Dialysis experiments revealed that, within the range of concentrations used, neither PVP nor methylcellulose was significantly bound to benzoic acid.Keywords
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