EXTREMELY HIGH LEVELS OF CORTICOSTEROIDS AND LOW LEVELS OF CORTICOSTEROID BINDING MACROMOLECULE IN PLASMA OF MARMOSET MONKEYS

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Abstract
Marmoset monkeys have extremely high resting plasma corticosteroid levels compared to those of macaque monkeys and humans. A major component of corticosteroids seems to be cortisol. Levels of total 11-deoxy-17-KS [ketosteroids] in plasma of marmoset monkeys were very low (< 0.01-0.04 .mu.g/ml). Following the injection of ACTH, plasma corticosteroid levels of marmoset monkeys increased by 18-62% (at 1 h), and by 62-160% (at 2 h). Concentrations of plasma corticosteroid binding macromolecule in marmoset monkeys were extremely low (< 10 nM). In these monkeys, the majority of plasma corticosteroids may exist in non-protein bound forms.