Extrapancreatic action of sulphonylureas: effect of gliquidone on insulin and glucagon binding to rat liver plasma membranes

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Abstract
Gliquidone (a 2nd generation sulfonylurea) was administered orally to normal rats 1 h before killing. Gliquidone treatment led to a decrease in plasma glucose, an increase in insulin and a diminution in glucagon concentration. Insulin binding to liver plasma membranes was enhanced by 40% in comparison with controls, whereas glucagon binding was slightly diminished. Liver cells have a greater sensitivity to insulin during sulfonylurea treatment and sulfonylureas potentiate insulin action on the liver.