Investigation of TSH Dependency, Circulating Thyroid Autoantibody, and Morphological Features of Recurrent Nontoxic Goitre

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Abstract
Pathogenetical factors possibly responsible for recurrence of nontoxic goiter in a nonendemic area are evaluated. A group of 22 female patients admitted for surgical treatment of recurrent nontoxic goiter was compared with a control group of 86 female nontoxic goitrous patients not operated upon before. Preoperative serum baseline thyrotropin (TSH) levels in the recurrent goiter group were low normal and did not differ significantly from those in the control group. Circulating thyroid microsomal autoantibodies, thyroglobulin antibody titers, and the densities of lymphocytic aggregation in goitrous tissue did not differ significantly in the 2 groups. Thus, none of the parameters studied were likely explanations of regrowth of goiter.