Ticrynafen in anephric patients: Effects on uric acid and pharmacokinetics
- 1 May 1980
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 27 (5) , 686-689
- https://doi.org/10.1038/clpt.1980.97
Abstract
Ticrynafen was given to 6 anephric patients undergoing maintenance hemodialysis. Ticrynafen was given daily for the 3 days between hemodialyses. Ticrynafen had no effect on the interdialysis rise in serum uric acid levels. Ticrynafen did not accumulate in serum, but levels of metabolites continued to rise over the 3 days. Hemodialysis (5 h) reduced levels of ticrynafen by 38% but had less effect on metabolite levels. There was no effect on serum cholesterol or triglycerides.This publication has 1 reference indexed in Scilit:
- GLC Determination of Ticrynafen and Its Metabolites in Urine, Serum, and Plasma of Humans and AnimalsJournal of Pharmaceutical Sciences, 1978